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The activated ligase-AMP intricate is now transferred towards the five’ phosphate group for the breaking position, and AMP interacts with the phosphate team releasing the ligase enzyme, Hence activating the 5’ finish of single-strand DNA.
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DNA ligase 3: complexes with DNA mend protein XRCC1 to help in sealing DNA through the entire process of nucleotide excision restore and recombinant fragments. From the all acknowledged mammalian DNA ligases, only ligase 3 is found being present in mitochondria.
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DNA ligase II: purification or excision fix of alternatively spliced kind of DNA ligase III located in non-dividing cells.
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